This article is part of our FanDuel Fantasy Soccer series.
For detailed odds and stats, check out the Fantasy Premier League: Wednesday Cheat Sheet.
2:45 p.m: Arsenal v. Leicester City
2:45 p.m: Middlesbrough v. Sunderland
3:00 p.m: Crystal Palace v. Tottenham
Wayne Hennessey, CRY v. TOT ($6,400): Hennessey has the highest save upside given Spurs force to most saves per game among the teams on Wednesday's slate. Additionally, he may not get lit up like many of the goalkeepers that Spurs have faced recently, as Hennessey comes in with three clean sheets in his last four matches at Selhurst Park. Even if he does concede (and he probably will), the saves should more than make up for it.
Rob Holding, ARS v. LEI ($4,500): With Arsenal's move to a three-man back line, Holding comes back into the fantasy conversation thanks to Shkodran Mustafi's injury absence. Holding is far from a high-impact fantasy performer, but he shouldn't have to do too much to pay off his salary, and he'll be facing a Leicester side that has forced the second-most clearances per game among teams on the slate.
Martin Kelly, CRY v. TOT ($5,400): Kelly has filled in well at center-back over the last four games, and while his stats don't jump off the page, his low salary will come in handy, particularly as he faces a Spurs team that has had the most shots blocked as well as the most tackles won and most passes intercepted against them among teams on the slate.
Calum Chambers, MID v. SUN ($5,400): Chambers was solid in his return last weekend against Bournemouth, scoring 19 fantasy points, which was solid production for $5,500. His salary actually declined this week with Middlesbrough hosting 20th-place Sunderland, but Chambers has shown throughout this season that he's able to collect tackles, interceptions, blocked shots and clearances, and he's even capable of creating chances occasionally, though usually when he's out wide. Fellow Boro center-back Ben Gibson is the fourth-most expensive defender on the slate and isn't significantly better (if he is at all) than Chambers.
Christian Eriksen, TOT at CRY ($10,500): Eriksen has scored over 23 fantasy points in five consecutive Premier League matches, including three games with more than 31. His fine play goes even further back, as he has two goals on 29 shots (eight on goal) and four assists on 26 chances created over the last seven league matches. Despite playing away to Crystal Palace, Tottenham are still solid favorites, and fading Eriksen in cash is likely to be very detrimental. For those looking for a bit more risk to build into a GPP lineup, teammate Heung-Min Son ($9,200) has been excellent lately, scoring five goals on 18 shots (eight on goal) in his last four games, though the first one was in a 17-minute appearance off the bench.
Wahbi Khazri, SUN at MID ($5,000): Khazri deserves fantasy consideration any time he's in the starting XI, though the problem is that he doesn't have many starts this season. However, he was in the lineup for Sunderland's last game and finished with an incredible 45.5 fantasy points thanks to one goal on four shots (two on goal), five chances created and two fouls drawn. That performance should be more than enough to allow him to keep his starting spot, and he'll now try his luck against a Boro defense that has allowed nine goals in their last four matches.
Adama Traore, MID v. SUN ($5,600): Traore could get the start in place of the suspended Gaston Ramirez ($6,000), which would provide a solid attacking option against a dreadful Sunderland defense. While his goal upside isn't that high, Traore is solid at creating chances and drawing fouls, which comes in handy against a Sunderland side that has allowed 13.56 chances to be created against them per game this season, nearly three more than any other team on the slate.
Alexis Sanchez, ARS v. LEI ($12,400): Alexis is the most expensive player on the slate, but that isn't surprising given his tremendous upside and the fact that he's playing Leicester City at home. He continues to be a consistent source of chances created, as well as shots on goal and fouls drawn, which all give him a solid foundation in case he explodes for at least one goal.
Alvaro Negredo, MID v. SUN ($7,600): Negredo is expected to lead the line against a Sunderland side that's allowed the most goals, shots, shots on goal and chances created per game among teams on the slate. He's unlikely to provide much if he doesn't find the back of the net, but he surely has a great opportunity to get on the scoresheet against a side he picked up two assists against last time they played (granted, it was back in August). All of the other goal-dependent forwards have worse matchups, and many are more expensive.