In a day full of frustrating injuries, a suspected season-ending torn ACL suffered by Saquon Barkley stands out as especially painful.
It's been a while, but Aaron Rodgers looked like the genuine article in his dominant Week 1 effort against the Vikings on Sunday.
Derrick Henry ran for 211 yards and three touchdowns against Houston on Sunday, earning him the league rushing title in what's now one of the league's most crowded skill position offenses.
It was a costly home loss for the Seahawks on Sunday, as their recent loss of Rashaad Penny (ACL) was compounded by season-ending injuries to Chris Carson (hip) and C.J. Prosise (arm).
Julio Jones went berserk against the 49ers on Sunday, posting 134 of Atlanta's 210 receiving yards and scoring twice, including a last-second game winner in the 29-22 upset.
Austin Ekeler posted one of the most explosive and efficient box scores of recent memory against Jacksonville, totaling 213 yards and two touchdowns from scrimmage on just 12 touches.
The Dolphins managed the upset of the tailspinning Eagles, thanks primarily to the ongoing breakout campaign of DeVante Parker.
Chris Carson fumbled against Philadelphia in a game where Rashaad Penny went over triple-digit rushing yardage, bringing the former first-round pick back onto the fantasy radar.
Even with Amari Cooper in and out of the game due to injury, Dak Prescott gained in the MVP race by throwing for 444 yards and three touchdowns in a 35-27 victory over Detroit.
A late Kyler Murray interception undid the work of a three-touchdown connection with Christian Kirk, but the Arizona passing game appears to be on its way to an impressive product.
Lamar kept rolling against the Patriots, taking down what had been the NFL's best defense. He's on pace for 3,600 yards and 24 touchdowns passing to go with nearly 1,300 yards and 10 touchdowns rushing.
Jared Goff had another strong fantasy showing Sunday, but he's completed just 57.4 percent of his passes the last two weeks and hasn't completed 60 percent in a game in a month.
Aaron Rodgers had only eight touchdowns in his first six games but lit up the Raiders for six touchdowns Sunday, perhaps righting the ship.
Sam Darnold showed no rust following a difficult Week 1 and then a bout with mono, throwing for 338 yards and two touchdowns in the Jets' upset of Dallas.
Kyler Murray took his rushing production to a new height on Sunday, a good sign for him and the Arizona offense in general as it tries to move the chains more consistently.
David Montgomery struggled to move the ball against a tough Minnesota defense, but his mammoth workload from Sunday forecasts better days ahead.
Daniel Jones had to make his first start on the road, but the four-touchdown showing in the comeback win made for a memorable debut.
Justin Jackson has played well for the Chargers, but Austin Ekeler is thriving as a workhorse back and posted another strong box score Sunday.
Dak Prescott looks like a potentially elite fantasy quarterback now that he has Kellen Moore running the Dallas offense.
Leonard Fournette and Dalvin Cook got three-down usage in their preseason cameos, while Kerryon Johnson shared snaps with C.J. Anderson.
Jerry Donabedian evaluates the implications of preseason playing time in various backfields, including James Conner taking every snap with the first-team offense in Pittsburgh.
Jerry Donabedian tries to figure out an appropriate draft spot for Josh Gordon post-reinstatement.
Jerry Donabedian looks at snap counts from the first week of the preseason, explaining why O.J. Howard's every-down role with the starting offense is far more relevant than his lack of receiving production.
Expectations for Minnesota only rose following their 13-3 season in 2017, but the first of Kirk Cousins' three-year, $84 million deal ended in disappointment.
The Colts began the year 1-5, but Andrew Luck's emphatic Comeback Player of the Year performance in an 8-1 run has them in playoff position.
Tom Brady is still at least very good, but after leading the Patriots to just 10 points against Pittsburgh it's fair to wonder if the 41-year-old is no longer great.
The Cowboys can't stop winning ever since Amari Cooper escaped the Black Lodge that is the Oakland Raiders organization.
There might not be much hope in 2018 with his career otherwise at a crossroads, but the firing of Mike McCarthy might set Aaron Rodgers free in 2019.
Baker Mayfield headlined the show with his dismantling of the Bengals, but Lamar Jackson and Josh Allen gave their teams' fanbases cause for excitement, too.
The Saints wrapped up Carson Wentz on Sunday and wrapped up Philadelphia's playoff hopes with him in one of the most memorable letdown games of recent history.