Sometimes the obvious is the right call. Backing Tom Brady and the Patriots at Miami in Week 2.
Backing Carson Wentz and the Eagles at home against the Redskins narrowly over the Seahawks hosting the Bengals.
Saquon Barkley and the Giants, home against a Cowboys squad that's locked into the No,. 4 seed, are an option this week if pickings are slim.
Expect a lot of people to be on Marcus Mariota and the Titans, who draw the Redskins at home this week.
Matt Ryan and the Falcons are a good option at home against the Cardinals, but make sure most of the remaining owners in your pool aren't likely to use them too.
Chris Liss analyzes all 16 favorites as your choices are probably limited if you've made it this far.
A healthy Marcus Mariota and the Titans, home against the Jets, are a decent choice if the double-digit favorites are unavailable to you.
Chris likes Terrell Suggs and the Ravens hosting the Raiders this week.
Chris Liss likes Philip Rivers and the Chargers at home against the Broncos this week.
Pat Mahomes and the Chiefs are the obvious play, but Chris Liss lists 10 choices for you in case you've used up the top teams.
If you've used up the Chiefs and don't trust the Bears on the road, Kirk Cousins and the Vikings make for a decent pivot.
Chris Liss goes with the obvious here - Tom Brady and the Patriots on the road against the hapless Bills.
If you've used up the Rams and Chargers, Chris Liss likes Calais Campbell and the Jaguars at home against the Texans.
Chris Liss likes Aaron Rodgers and the Packers to handle their business at home against a banged-up 49ers squad
Chris Liss is taking the chalk with Tom Brady and the Patriots at home against the Colts on Thursday night.
After last week's bloodbath, Chris is picking Aaron Rodgers and the 18.6-percent-owned Packers at home against the Bills.
Unless you believe the Vikings will be 76-percent used (or higher), you're better off taking the chalk.
Chris Liss likes Aaron Donald and the Rams at home against the visiting Cardinals, despite LA's nearly 40 percent ownership.
Backing Drew Brees and the Saints at home against the Buccaneers who are without their starting quarterback.
Paxton Lynch and the Broncos get a home game against the Chiefs, who have locked up the No. 4 seed and have nothing for which to play. (Assuming our top nine choices aren't available to you.)
Joe Flacco and the Ravens are 13.5-point favorites at home against the hapless Colts.
There are three double-digit favorites on the slate including Blake Bortles and the Jaguars hosting the Texans.
Tough choices this week, but if Tyrod Taylor is cleared to play, the Bills become a viable option, home against the Colts.
Fade Philip Rivers and the Chargers if you think they'll be 80 percent owned or higher in your pools.
So many great choices like Ben Roethlisberger and the Steelers at home against the Brett Hundley-led Packers
Fading Travis Kelce and the Chiefs who are 55.5-percent owned against the Giants at the Meadowlands.
Fade the 58-percent owned Matthew Stafford Lions, despite being massive home favorites against the hapless Browns.
Chris Liss takes Deshaun Watson and the chalky Texans, who are 13-point home favorites against the Colts, even though the Texans are 50-percent owned.
Backing the chalk. Carson Wentz and the Eagles are 13-point home favorites against the visiting 49ers.
For the few of you still remaining, Chris makes his picks, leading with Harrison Smith and the Vikings hosting the Ravens.